程序代码：

using System;
using System.Collections.Generic;
using using System.Data;
using System.Drawing;
using System.Text;
using System.Windows.Forms;

namespace WindowsFormsApplication1
{
    public partial class Form1 : Form
    {
        /// <summary>
        /// 屏保From1, 在该窗体属性上 设为无边窗体，状态设为最大化
        /// </summary>
        public Form1()
        {
            InitializeComponent();
        }

        Point MousePosition;//p1用于获取屏保启动时鼠标位置
        private void Form1_Load(object sender, EventArgs e)
        {
            Cursor.Hide();//隐藏鼠标
            MousePosition = new Point(Cursor.Position.X,Cursor.Position.Y);//记下鼠标初始位置
            timer1.Start();
        }

        private void Form1_KeyPress(object sender, KeyPressEventArgs e)//按下键盘时，屏保关闭
        {
            this.Close();
        }
       
        //通过计时器判断鼠标位置是否改变
        private void timer1_Tick(object sender, EventArgs e)
        {
            if(MousePosition != Cursor.Position)//鼠标位置改变时,屏保关闭
            {
                this.Close();
            }
        }
        private void Form1_Deactivate(object sender, EventArgs e)//当前窗体被挂起时，屏保关闭
        {
            this.Close();
        }
        private void Form1_MouseClick(object sender, MouseEventArgs e)//鼠标点击时，屏保关闭
        {
            this.Close();
        }
    }
}